Confronting Cancer as a Community
Description
Brief Summary
This study aims to better understand the cause of colorectal cancer and how to find the best
treatment for Hispanic patients with colorectal cancer. The genetic information in the blood
and tissues may explain why patients who have the same type of cancer and receive the same
treatment do not always have the same results. By combining genetic (certain qualities or
traits passed from parents to offspring) information with clinical data, such as the
responses of different kinds of cancers to different treatments, this study could lead to
more knowledge about why certain cancers occur and why they respond differently to
treatments. Information gathered from this study may help researchers match treatments to the
genetics of each patient and the genetic changes in their tumor. This approach is known as
personalized medicine.
Detailed Description
PRIMARY OBJECTIVE:
I. To create a well-characterized cohort of Hispanic patients with colon cancer, with
patient-level data, genomic, transcriptomic, clinical, and outcomes data.
SECONDARY OBJECTIVES:
I. To identify genomic/transcriptomic predictors of treatment outcomes (time to recurrence,
time to progression, and overall survival).
II. To identify associations between somatic tumor deoxyribonucleic acid (DNA) methylation
patterns and clinical outcomes.
III. To examine patterns of patient engagement in genetic/genomic testing among Hispanic
patients with colorectal cancer (CRC).
IV. To characterize the gut microbiome through a stool collection kit and nucleic acid
extraction process.
EXPLORATORY OBJECTIVES:
I. To validate, characterize and discover molecular processes in the CRC tumor common to
other CRC populations and specific to Hispanic patients.
II. To determine whether comorbidities are associated with variation in tumor molecular
pathways and whether comorbidities are effect modifiers of associations between tumor
molecular variation and disease outcomes and response to treatment in Hispanic CRC patients.
OUTLINE: This is an observational study.
Patients undergo blood sample collection, collection of archival tumor tissue and genetic
testing, and complete questionnaires on study. Patients also have their medical records
reviewed on study.
After return of genetic testing results, patients are followed up at 2 weeks, 12 months, and
then annually thereafter.
Phase
N/AInclusion and Exclusion Criteria
- Self-reported Hispanic ethnicity
- Diagnosed with colon or rectal cancer (at any time and stage; lifetime diagnosis and in survival are eligible)
- Has a tumor tissue sample archived or plans to have tissue archived from a standard care procedure
- Age >= 18 years
- Inability to understand and the willingness to sign a written informed consent
Sites
Please contact the trial administrator to learn more about where you can participate in this trial. Please use the contact form on the right side.
Presentado por
SC CTSI