Cognition as a moderator of motor learning post-stroke
The goal of this study is to understand how an individual’s cognitive function and brain structure may influence their ability to learn a new walking pattern. We hope to learn how people can best learn a new walking pattern when parts of the brain are damaged and cognitive function may be impaired.
Healthy Minds Volunteer Database
The Healthy Minds Volunteers (http://healthyminds.usc.edu) help research labs at the University of Southern California. These labs are working towards a greater understanding of how aging can affect physical, mental and emotional health. The goal is to learn how we can maintain healthy minds and bodies across our lifespan.
VNS Therapy for Treatment-Resistant Depression
The purpose of this study is to track active VNS Therapy treatment in subjects with Treatment-Resistant Depression (TRD) and to better understand the reduction in the severity of baseline TRD symptoms. Data will be collected on your responses to study treatments, quality of life, productivity, and your use of healthcare services. Your participation in this study will consist of evaluations by the study doctor (or his/her designee), who will review your past and current medical and psychiatric history, and several questionnaires which you will complete during several follow-up visits over time.
Recruiting | treatment resistant depression | Not Multisite
A pilot study of safety and efficacy of spectroscopic diagnosis of pancreatic lesions (Spy Panc)
The objective of this study is to determine if a minimally invasive optical probe can accurately predict a histological diagnosis of dysplastic or malignant tumor cells in solid lesions of the pancreas. If effective, this optical probe would facilitate the detection of malignant and pre-malignant pancreatic lesions. This would lead to more accurate decision-making as to which patients require surgical resection versus patients who should be spared from major surgery.
Examining the factors that influence stroke survivor's walking in their homes and communities
Physical therapy interventions to improve walking after stroke are typically designed to focus on impairments such as endurance, strength, speed, or balance. However, walking restrictions after a stroke are only partially related to these impairments. As such, improving these impairments does not necessarily result in increased walking in individuals' homes or communities. The goal of this study is to more thoroughly examine factors related to real-world walking, including motivation, confidence, and fatigue. This research will provide insight to better translate the improvements made during physical therapy to real-world activity.
Tirzepatide Alcohol Outcomes Study (TAOS)
This clinical trial is investigating the effects of a GLP-1-based medication, tirzepatide, on alcohol-related outcomes in adults seeking to reduce or quit drinking.
Diagnostic Fetal Imaging on a Novel MRI Scanner
We are seeking pregnant adults to participate in a study evaluating a novel, quieter MRI scanner. We hope to develop better ways for doctors to screen pregnancies for possible fetal problems and to make MRI of unborn babies more comfortable and even safer. Images will be collected at 3-6 fold lower magnetic field strength (0.55 Tesla) than a standard MRI. Participation in this study will involve being imaged on a lower field strength MRI scanner located in the Michelson Building at the USC University Park Campus. Participants will be compensated for their time.
A Placebo-controlled Study of a Targeted Immune Therapy Drug in Subjects with Moderate to Severe Ulcerative Colitis (UC)
The primary objective of this study is to study the effectiveness of a novel targeted immune therapy (biologic) called LY3074828 in treating moderate to severe ulcerative colitis. This study will take place over 120 weeks and all study visits and procedures will be provided at no cost to you. During the initial part of this study, patients will either receive LY3074828, or placebo ("dummy" treatment). Patients who receive placebo initially will have the opportunity to receive the study drug LY3074828 later in the study.
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